While part of a longer talk, we will be reviewing the highlights including:
* Identify what is truly slow and high volume queries
* Choosing the right indexes including unique indexes, concatenated and partical indexes
* Choosing the right storage engines (MyISAM, InnoDB and Memory)
* Removing load including synchronous/real-time queries, master load, locking and sharding
* The best performance improvement for a SQL statement is to eliminate it
* Quantifying improvements made 

The 10 Points are:
# Monitor, Monitor, Monitor
# Identify problem SQL
# Analyze problem SQL
# Indexes
# Offloading master load
# Improving SQL
# Storage engines
# Caching
# Sharding
# Handling database maintenance 

Bonus: Front end improvements